反应详情

温度

190 °C

A mixture of 2.5 g of product from Example 99 and 1.17 g of 3,4-pyridinecarboxylic anhydride is heated, in a sealed tube, at 190° C. for 12 minutes. The cooled crystalline product is dissolved in chloroform, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue is purified by chromatography (silica gel: 30-40% ethyl acetate/hexane) to give 3.12 g of the desired product as colorless crystals.

1. dry with materialdried over anhydrous sodium sulfate
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customThe residue is purified by chromatography (silica gel: 30-40% ethyl acetate/hexane)