1H,3H-furo(3,4-c)pyridine-1,3-dione → 2-[[4-(Tetradecyloxy)phenyl]methyl]-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.5 g of product from Example 99 and 1.17 g of 3,4-pyridinecarboxylic anhydride is heated, in a sealed tube, at 190° C. for 12 minutes. The cooled crystalline product is dissolved in chloroform, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue is purified by chromatography (silica gel: 30-40% ethyl acetate/hexane) to give 3.12 g of the desired product as colorless crystals.

Provenance & Evidence