HRID248035

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccncc2)C(C)=O)cc1C(C)(C)C

HCID10481861

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cc[n+](C)cc2)C(C)=O)cc1C(C)(C)C.[I-]

HCID10484536

未命名化合物

收率 97.5%

PROCEDURE

实验过程

A mixture of 0.225 g of product from Example 138 and 6.11 g of methyl iodide is heated in a sealed tube, in the dark, at 105° C. for 18 hours. The reaction is concentrated in vacuo to give 0.279 g of the desired product as orange crystals.

WORKUP

后处理

temperatureis heated in a sealed tube
concentrationThe reaction is concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b2b80013b89545fba021af8cc5b6ac34
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05208247
来源说明: uspto-grants-1993_05

反应 SMILES

[C:1]([N:4]([CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[C:5](=[O:31])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:8]([C:27]([CH3:30])([CH3:29])[CH3:28])[CH:7]=1)(=[O:3])[CH3:2].[CH3:39][I:40]>>[I-:40].[C:1]([N:4]([CH2:32][C:33]1[CH:34]=[CH:35][N+:36]([CH3:39])=[CH:37][CH:38]=1)[C:5](=[O:31])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:8]([C:27]([CH3:28])([CH3:29])[CH3:30])[CH:7]=1)(=[O:3])[CH3:2]