反应详情

Dissolve (+)-2-[4-[2-(2,3,6,9-tetrahydro-1,3-dipropyl 2,6-dioxo-1H-purin-8-yl)propyl]phenoxy]acetic acid, ethyl ester (0.49 g, 1.07 mmol) in ethanol (10 mL) and treat with a solution of potassium hydroxide (0.072 g, 1.29 mmol) in water (10 mL). Stir for 3 hours, then dilute with water (200 mL) and acidify with 10% hydrochloric acid. Extract into chloroform (2×400 mL), then ether (400 mL) and dry (MgSO4). Evaporate the solvent in vacuo to give the title compound as a white solid (0.33 g, 72%); [α]d 20 =+81° (C=0.069, DMSO).

1. extractionExtract into chloroform (2×400 mL)
2. dry with materialether (400 mL) and dry (MgSO4)
3. customEvaporate the solvent in vacuo