1,4-Dioxane → HCID 178456501, compound

HRID 248092Notes

Reaction equation

HRID 248092 reaction equation
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10]=[C:9]([CH:14]([CH3:36])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]([NH:26][C@H:27]([C:29]([O:31]C(C)(C)C)=[O:30])[CH3:28])=[O:25])=[CH:18][CH:17]=3)[NH:8][C:7]=2[N:6]([CH2:37][CH2:38][CH3:39])[C:5]1=[O:40])[CH2:2][CH3:3].O1CCOCC1>Cl>[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10]=[C:9]([CH:14]([CH3:36])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]([NH:26][C@H:27]([C:29]([OH:31])=[O:30])[CH3:28])=[O:25])=[CH:18][CH:17]=3)[NH:8][C:7]=2[N:6]([CH2:37][CH2:38][CH3:39])[C:5]1=[O:40])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 178456502HCID 178456502, compound

Product 1

HCID 178456501HCID 178456501, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolve (-)-N-[[[4-[2-(2,3,6,9-tetrahydro-1,3-dipropyl-2,6-dioxo-1H-purin-8-yl)propy]phenyl]oxy]acetyl]-L-alanine, t-butyl ester (5.55 g, 10 mmol) in 4N hydrochloric acid in dioxane (25 mL, 100 mmol) and stir for several hours. Evaporate the solvent in vacuo and purify by ion-exchange chromatography to give the title compound.

Workup

  1. customEvaporate the solvent in vacuo
  2. custompurify by ion-exchange chromatography

Sources & evidence

ORD record
ord-2c4471c9134a4d549479208998d2b80b
Source dataset
uspto-grants-1993_05
Patent number
US05208240

Reaction notes

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