4-(3-Mercaptophenyl)-4-methoxytetrahydropyran → 4-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyran

HRID 248097Notes

Reaction equation

HRID 248097 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14](I)[CH:13]=[CH:12][C:3]=1[N:4]([CH3:11])[C:5](=[O:10])[C:6]([F:9])([F:8])[F:7].[SH:17][C:18]1[CH:19]=[C:20]([C:24]2([O:30][CH3:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>>[Cl:1][C:2]1[CH:15]=[C:14]([S:17][C:18]2[CH:19]=[C:20]([C:24]3([O:30][CH3:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[CH:21]=[CH:22][CH:23]=2)[CH:13]=[CH:12][C:3]=1[N:4]([CH3:11])[C:5](=[O:10])[C:6]([F:9])([F:8])[F:7]

Participants

3

Reactant 2

HCID 193757154-(3-Mercaptophenyl)-4-methoxytetrahydropyranHCID 197647922'-chloro-4'-iodo-2,2,2-trifluoro-N-methylacetanilide

Product 1

HCID 197647794-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyranYield 8%

Procedure

Using a similar procedure to that described in Example 12, 2'-chloro-4'-iodo-2,2,2-trifluoro-N-methylacetanilide was reacted with 4-(3-mercaptophenyl)-4-methoxytetrahydropyran to give 4-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyran in 8% yield as a gum.

Sources & evidence

ORD record
ord-cd6a5f2563f445b5a5d11af295b098e6
Source dataset
uspto-grants-1993_05
Patent number
US05208259

Reaction notes

Loading…