HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Mercaptophenyl)-4-methoxytetrahydropyran → 4-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Mercaptophenyl)-4-methoxytetrahydropyran | HCID 19375715 | — |
| Reactant | 2'-chloro-4'-iodo-2,2,2-trifluoro-N-methylacetanilide | HCID 19764792 | — |
| Product | 4-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyran | HCID 19764779 | 8% |
Reaction Steps
Using a similar procedure to that described in Example 12, 2'-chloro-4'-iodo-2,2,2-trifluoro-N-methylacetanilide was reacted with 4-(3-mercaptophenyl)-4-methoxytetrahydropyran to give 4-[3-(3-chloro-4-(N-methyltrifluoroacetamido)phenylthio)phenyl]-4-methoxytetrahydropyran in 8% yield as a gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05208259 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-cd6a5f2563f445b5a5d11af295b098e6 |
| Source note | uspto-grants-1993_05 |