Methyl iodide → HCID 21657770, compound

HRID 248101Notes

Reaction equation

[CH2:1]([CH:3]1[CH2:8][C:7]([OH:26])([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15][C:16]3[CH:21]=[CH:20][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=3)[CH:10]=2)[CH2:6][CH2:5][O:4]1)[CH3:2].[CH3:27]I>>[CH2:1]([CH:3]1[CH2:8][C:7]([O:26][CH3:27])([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15][C:16]3[CH:17]=[CH:18][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:20][CH:21]=3)[CH:10]=2)[CH2:6][CH2:5][O:4]1)[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 67837083HCID 67837083, compound

Product 1

HCID 21657770HCID 21657770, compoundYield 57%

Procedure

Using a similar procedure to that described in Example 3, (2SR,4SR)-2-ethyl-4-hydroxy-4-[3-(4-tert-butylphenylthio)phenyl]tetrahydropyran was reacted with methyl iodide to give (2SR,4SR)-2-ethyl-4-methoxy-4-[3-(4-tert-butylphenylthio)phenyl]tetrahydropyran in 57% yield as an oil.

Sources & evidence

ORD record: ord-74fd289f5ab4460aa37a41e7f7a47cc5
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05208259

Reaction notes

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