反应详情

A mixture of 56.1 g of propargyl alcohol in 100 ml of tetrahydrofuran and 15.6 g of lithium in 1 liter of ammonia containing a trace of ferric chloride is stirred for 1 hour. A 76.4 ml portion of hexadecyl bromide is added and the mixture refluxed for 8 hours then evaporated. The residue is dissolved in ether and washed with 10% hydrochloric acid, dried and purified by flash chromatography, to give 47.4 g of the desired compound as white platelets, mp. 60° C.

1. temperaturethe mixture refluxed for 8 hours
2. customthen evaporated
3. dissolutionThe residue is dissolved in ether
4. washwashed with 10% hydrochloric acid
5. customdried
6. custompurified by flash chromatography