Sodium Hydroxide → HCID 178485770, compound

HRID 24819Notes

Reaction equation

HRID 24819 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:16](OCC)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]1=[O:26])(=O)C.[CH2:27]([N:34]1[CH2:39][CH2:38][N:37]([CH2:40][C:41]([N:43]([C:45]2[CH:51]=[CH:50][C:48]([NH2:49])=[CH:47][CH:46]=2)[CH3:44])=[O:42])[CH2:36][CH2:35]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[OH-].[Na+]>CN(C=O)C.CO>[CH2:27]([N:34]1[CH2:35][CH2:36][N:37]([CH2:40][C:41]([N:43]([C:45]2[CH:46]=[CH:47][C:48]([NH:49]/[C:16](=[C:6]3\[C:5](=[O:26])[NH:4][C:12]4[C:7]\3=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=4)/[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:50][CH:51]=2)[CH3:44])=[O:42])[CH2:38][CH2:39]1)[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 225695334-[N-(4-benzylpiperazinomethylcarbonyl)-N-methylamino]-anilineHCID 542801041-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone

Product 1

HCID 178485770HCID 178485770, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-[N-(4-benzylpiperazinomethylcarbonyl)-N-methyl-amino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-65424f129b7c46ebbe85b8d5fe181b20
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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