反应详情

A mixture of 0.3 mol of 4-trifluoromethylphenol, 1000 ml of ethanol and 20 g of rhodium/activated charcoal (5%) is hydrogenated for 2 hours at a pressure of 5 bar and a temperature of 60° C. Removal of the solid components by filtration and removal of the solvent by distillation give the cyclohexanol as a cis/trans mixture (30%/70%). From this, the pure trans-compound is obtained by heating with aluminium triisopropylate in toluene in the presence of 3,3-dimethyl-2-butanone and subsequent recrystallization.

1. customa temperature of 60° C
2. customRemoval of the solid components
3. filtrationby filtration and removal of the solvent
4. distillationby distillation