Hydrochloric Acid → HCID 178520943, compound

HRID 248304Notes

Reaction equation

HRID 248304 reaction equation
[F:1][C:2]([F:13])([F:12])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=[O:10])[CH2:5][CH2:4]1.C([Mg]Br)C(C)C.CCOCC.Cl>>[F:1][C:2]([F:12])([F:13])[C@H:3]1[CH2:4][CH2:5][C@H:6]([CH:9]=[O:10])[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178418816HCID 178418816, compoundHCID 178525710HCID 178525710, compound

Product 1

HCID 178520943HCID 178520943, compound

Procedure

0.05 mol of trans-4-trifluoromethylcyclohexanecarboxylic acid (prepared as in Example 1) is added dropwise to 100 ml of a solution of isobutylmagnesium bromide in ether (1 mol/1) and 0.3 mmol of dichlorobis[π-cyclopentadienyl]titanium at 0° C., and the mixture is stirred at room temperature for 4 hours. 30 ml of a 4 normal hydrochloric acid are added, and customary workup gives the product as a colourless oil.

Sources & evidence

ORD record
ord-4dcd51a8f4614c6ea93254b6b98520bd
Source dataset
uspto-grants-1993_05
Patent number
US05209868

Reaction notes

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