HCID 178443557, compound → HCID 178443565, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.11 mol of trans-4-heptylcyclohexylmethyl bromide and 80 ml of THF is added at 0° C. to a mixture of 0.1 mol of sodium (trans-4-trifluoromethylcyclohexanolate) (prepared from 0.1 mol of trans-4-trifluoromethylcyclohexanol and 0.1 mol of sodium hydride) and 200 ml of THF. The mixture is stirred at 60° C. for 3 hours, and customary work-up gives the product as a colourless solid.

Provenance & Evidence