HCID 178443557, compound → HCID 178443565, compound

HRID 248306Notes

Reaction equation

HRID 248306 reaction equation
[CH2:1]([C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14]Br)[CH2:10][CH2:9]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[F:16][C:17]([F:26])([F:25])[C@H:18]1[CH2:23][CH2:22][C@H:21]([O-:24])[CH2:20][CH2:19]1.[Na+]>C1COCC1>[F:16][C:17]([F:25])([F:26])[C@H:18]1[CH2:19][CH2:20][C@H:21]([O:24][CH2:14][C@H:11]2[CH2:12][CH2:13][C@H:8]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:9][CH2:10]2)[CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 178443557HCID 178443557, compoundHCID 178507101HCID 178507101, compound

Product 1

HCID 178443565HCID 178443565, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
60 °C

Procedure

A mixture of 0.11 mol of trans-4-heptylcyclohexylmethyl bromide and 80 ml of THF is added at 0° C. to a mixture of 0.1 mol of sodium (trans-4-trifluoromethylcyclohexanolate) (prepared from 0.1 mol of trans-4-trifluoromethylcyclohexanol and 0.1 mol of sodium hydride) and 200 ml of THF. The mixture is stirred at 60° C. for 3 hours, and customary work-up gives the product as a colourless solid.

Sources & evidence

ORD record
ord-bd4571363ff143c68cb7f71e6506ef85
Source dataset
uspto-grants-1993_05
Patent number
US05209868

Reaction notes

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