Hydrazine → HCID 15670095, compound

HRID 248344Notes

Reaction equation

HRID 248344 reaction equation
NN.[O:3]([CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH2:18][CH2:19][N:20]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:12]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CCO>[O:3]([CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH2:18][CH2:19][NH2:20])[CH2:12]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 19763379HCID 19763379, compound

Product 1

HCID 15670095HCID 15670095, compoundYield 61.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.9 ml (0.06 mol) of hydrazine are added to 11.3 g (0.03 mol) of 2-{3-[3-(phenoxymethyl)-1-piperidyl]propyl}-1H-isoindole-1,3(2H)-dione in 226 ml of EtOH. The mixture is heated to the refluxing temperature while stirring for 3 h. It is left to cool and filtered, the filter is rinsed with EtOH and the filtrate is concentrated. The residue is taken up with ether. The filtrate is concentrated and 4.6 g of yellow oil are obtained.

Workup

  1. temperatureThe mixture is heated to the refluxing temperature
  2. waitIt is left
  3. temperatureto cool
  4. filtrationfiltered
  5. washthe filter is rinsed with EtOH
  6. concentrationthe filtrate is concentrated
  7. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-0baa29b9478b435f9021fd93cfbe0d32
Source dataset
uspto-grants-1993_05
Patent number
US05210086

Reaction notes

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