反应详情

温度

200 °C

A mixture of 4-bromo-1-(4-methylphenyl)pyrrole-2-carbonitrile (3.66 g), sodium trifluoroacetate (7.62 g), cuprous iodide (5.34 g) and N-methylpyrrolidone (40 ml) was stirred at 200° C. under a nitrogen atmosphere for 11 hours. The mixture was filtered. The filtrate was poured into water and extracted with ethyl acetate twice. The combined organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography to afford 1-(4-methylphenyl)-4-trifluoromethylpyrrole-2-carbonitrile (0.98 g).

1. filtrationThe mixture was filtered
2. additionThe filtrate was poured into water
3. extractionextracted with ethyl acetate twice
4. dry with materialThe combined organic layer was dried over magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was purified by silica gel column chromatography