HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[(N-methylpiperazinyl)methyl]-1,4-bis(phenylmethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1,4-Dibenzyl-2-(chloromethyl)piperazine | HCID 10663119 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[(N-methylpiperazinyl)methyl]-1,4-bis(phenylmethyl)piperazine | HCID 54418979 | 95.1% |
Reaction Steps
A mixture of 7.7 g of 2-chloromethyl-1,4-bis(phenylmethyl)piperazine, 12 g of N-methylpiperazine, 3.5 g of potassium carbonate, 150 ml of dioxane and 60 ml of water was heated overnight at 80°-90° C. and then evaporated. The residual gum was dissolved in dichloromethane, washed with water, dried, filtered and evaporated, giving 8.8 g of 2-[(N-methylpiperazinyl)methyl]-1,4-bis(phenylmethyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05210193 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-77e3e6130e024acd90f7b015a1545967 |
| Source note | uspto-grants-1993_05 |