反应详情

A mixture of 7.7 g of 2-chloromethyl-1,4-bis(phenylmethyl)piperazine, 12 g of N-methylpiperazine, 3.5 g of potassium carbonate, 150 ml of dioxane and 60 ml of water was heated overnight at 80°-90° C. and then evaporated. The residual gum was dissolved in dichloromethane, washed with water, dried, filtered and evaporated, giving 8.8 g of 2-[(N-methylpiperazinyl)methyl]-1,4-bis(phenylmethyl)piperazine.

1. temperaturewas heated overnight at 80°-90° C.
2. customevaporated
3. dissolutionThe residual gum was dissolved in dichloromethane
4. washwashed with water
5. customdried
6. filtrationfiltered
7. customevaporated