Formic Acid → HCID 14839361, compound

HRID 248492Notes

Reaction equation

HRID 248492 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]3[NH:15][CH2:14][CH2:13][N:12]([C:16]4[CH:25]=[C:24]5[C:19]([C:20](=[O:31])[C:21]([C:28]([OH:30])=[O:29])=[CH:22][N:23]5[CH2:26][CH3:27])=[CH:18][C:17]=4[F:32])[CH2:11]3)=[CH:7][C:6]=2[CH:33]=1.[CH:34](O)=O>C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]3[N:15]([CH3:34])[CH2:14][CH2:13][N:12]([C:16]4[CH:25]=[C:24]5[C:19]([C:20](=[O:31])[C:21]([C:28]([OH:30])=[O:29])=[CH:22][N:23]5[CH2:26][CH3:27])=[CH:18][C:17]=4[F:32])[CH2:11]3)=[CH:7][C:6]=2[CH:33]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 14839360HCID 14839360, compound

Product 1

HCID 14839361HCID 14839361, compound

Reagents, catalysts & solvents 1

HCID 712FormaldehydeSolvent

Procedure

A 150 mg portion of 7-[3-(5-chloro-2-benzofuranyl)-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was suspended in 0.6 ml of 37% formaldehyde and 0.75 ml of 90% formic acid was added. The mixture was heated on a steam bath for 2 hours, then evaporated to dryness. A 5 ml portion of water was added, the pH adjusted to 7.0 with 1N sodium hydroxide and the solid collected, washed with water and dried, giving 113 mg of the desired product, mp 248°-249° C.

Workup

  1. temperatureThe mixture was heated on a steam bath for 2 hours
  2. customevaporated to dryness
  3. additionA 5 ml portion of water was added
  4. customthe solid collected
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-7c96fd8f95374bdea9791467f8a63483
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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