Formic Acid → HCID 14839361, compound

Participants

Reaction Steps

A 150 mg portion of 7-[3-(5-chloro-2-benzofuranyl)-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was suspended in 0.6 ml of 37% formaldehyde and 0.75 ml of 90% formic acid was added. The mixture was heated on a steam bath for 2 hours, then evaporated to dryness. A 5 ml portion of water was added, the pH adjusted to 7.0 with 1N sodium hydroxide and the solid collected, washed with water and dried, giving 113 mg of the desired product, mp 248°-249° C.

Provenance & Evidence