Triethylamine → HCID 178473949, compound

HRID 24857Notes

Reaction equation

HRID 24857 reaction equation
Cl[C:2](=[C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([N+:30]([O-:32])=[O:31])[CH:28]=2)[N:23]([C:33](=[O:35])[CH3:34])[C:22]1=[O:36])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:14](=[O:15])[C:13]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]3[C:11]2=[O:20])=[CH:5][CH:4]=1.[C:37]([O:41][C:42]([NH:44][CH2:45][C:46]1[CH:52]=[CH:51][C:49]([NH2:50])=[CH:48][CH:47]=1)=[O:43])([CH3:40])([CH3:39])[CH3:38].C(N(CC)CC)C>ClCCl>[C:37]([O:41][C:42]([NH:44][CH2:45][C:46]1[CH:52]=[CH:51][C:49]([NH:50]/[C:2](=[C:21]2\[C:22](=[O:36])[N:23]([C:33](=[O:35])[CH3:34])[C:24]3[C:29]\2=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)/[C:3]2[CH:8]=[CH:7][C:6]([CH2:9][N:10]3[C:14](=[O:15])[C:13]4=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]4[C:11]3=[O:20])=[CH:5][CH:4]=2)=[CH:48][CH:47]=1)=[O:43])([CH3:40])([CH3:38])[CH3:39]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2756041tert-butyl N-[(4-aminophenyl)methyl]carbamateHCID 697410191-Acetyl-3-[1-chloro-1-(4-phthalimidomethyl-phenyl)-methylidene]-5-nitro-2-indolinone

Product 1

HCID 178473949HCID 178473949, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 2c from 3-[1-chloro-1-(4-phthalimidomethyl-phenyl)-methylidene]-1-acetyl-5-nitro-2-indolinone, 4-tert.butoxycarbonylaminomethyl-aniline and triethylamine in dichloromethane.

Sources & evidence

ORD record
ord-8c2f48ac134147ed85f0a7065cf53d34
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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