HRID24857

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID2756041

4-(N-Boc-aminomethyl)aniline

C12H18N2O2

结构：CC(=O)N1C(=O)C(=C(Cl)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21

HCID69741019

未命名化合物

PRODUCTS

生成物

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(CNC(=O)OC(C)(C)C)cc2)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21$

HCID178473949

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared analogously to Example 2c from 3-[1-chloro-1-(4-phthalimidomethyl-phenyl)-methylidene]-1-acetyl-5-nitro-2-indolinone, 4-tert.butoxycarbonylaminomethyl-aniline and triethylamine in dichloromethane.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c2f48ac134147ed85f0a7065cf53d34
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

Cl[C:2](=[C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([N+:30]([O-:32])=[O:31])[CH:28]=2)[N:23]([C:33](=[O:35])[CH3:34])[C:22]1=[O:36])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:14](=[O:15])[C:13]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]3[C:11]2=[O:20])=[CH:5][CH:4]=1.[C:37]([O:41][C:42]([NH:44][CH2:45][C:46]1[CH:52]=[CH:51][C:49]([NH2:50])=[CH:48][CH:47]=1)=[O:43])([CH3:40])([CH3:39])[CH3:38].C(N(CC)CC)C>ClCCl>[C:37]([O:41][C:42]([NH:44][CH2:45][C:46]1[CH:52]=[CH:51][C:49]([NH:50]/[C:2](=[C:21]2\[C:22](=[O:36])[N:23]([C:33](=[O:35])[CH3:34])[C:24]3[C:29]\2=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)/[C:3]2[CH:8]=[CH:7][C:6]([CH2:9][N:10]3[C:14](=[O:15])[C:13]4=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]4[C:11]3=[O:20])=[CH:5][CH:4]=2)=[CH:48][CH:47]=1)=[O:43])([CH3:40])([CH3:38])[CH3:39]