HRID24858

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24654

Hydrazine hydrate (1:1)

H6N2O

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(CNC(=O)OC(C)(C)C)cc2)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21$

HCID178473949

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccc(CN)cc2)cc1$

HCID178453077

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Prepared analogously to Example 139b from (Z)-3-[1-(4-tert.butoxycarbonylaminomethyl-phenylamino)-1-(4-phthalimidomethyl-phenyl)-methylidene]-1-acetyl-5-nitro-2-indolinone and hydrazine hydrate solution in ethanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1cc3f66a7bc4a29ad7a3fe868d12d39
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:36]2\[C:37](=[O:51])[N:38](C(=O)C)[C:39]3[C:44]\2=[CH:43][C:42]([N+:45]([O-:47])=[O:46])=[CH:41][CH:40]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][N:25]3C(=O)C4=CC=CC=C4C3=O)=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.NN>C(O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:36]2\[C:37](=[O:51])[NH:38][C:39]3[C:44]\2=[CH:43][C:42]([N+:45]([O-:47])=[O:46])=[CH:41][CH:40]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][NH2:25])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]