Hydrazine hydrate (1:1) → HCID 178453077, compound

HRID 24858Notes

Reaction equation

HRID 24858 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:36]2\[C:37](=[O:51])[N:38](C(=O)C)[C:39]3[C:44]\2=[CH:43][C:42]([N+:45]([O-:47])=[O:46])=[CH:41][CH:40]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][N:25]3C(=O)C4=CC=CC=C4C3=O)=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.NN>C(O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:36]2\[C:37](=[O:51])[NH:38][C:39]3[C:44]\2=[CH:43][C:42]([N+:45]([O-:47])=[O:46])=[CH:41][CH:40]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][NH2:25])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178473949HCID 178473949, compound

Product 1

HCID 178453077HCID 178453077, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 139b from (Z)-3-[1-(4-tert.butoxycarbonylaminomethyl-phenylamino)-1-(4-phthalimidomethyl-phenyl)-methylidene]-1-acetyl-5-nitro-2-indolinone and hydrazine hydrate solution in ethanol.

Sources & evidence

ORD record
ord-f1cc3f66a7bc4a29ad7a3fe868d12d39
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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