Hydrazine hydrate (1:1) → HCID 178453290, compound

HRID 24862Notes

Reaction equation

HRID 24862 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:37]2\[C:38](=[O:52])[N:39](C(=O)C)[C:40]3[C:45]\2=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:26]3C(=O)C4=CC=CC=C4C3=O)=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.NN>C(O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH:17]/[C:18](=[C:37]2\[C:38](=[O:52])[NH:39][C:40]3[C:45]\2=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH2:26])=[CH:21][CH:20]=2)=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178473948HCID 178473948, compound

Product 1

HCID 178453290HCID 178453290, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 140 from (Z)-3-{1-[4-(2-tert.butoxycarbonylamino-ethyl)-phenylamino]-1-(4-phthalimidomethyl-phenyl)-methylidene}-1-acetyl-5-nitro-2-indolinone and hydrazine hydrate solution in ethanol.

Sources & evidence

ORD record
ord-fcd9165954f54a5a90748585608b9c50
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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