HRID24862

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24654

Hydrazine hydrate (1:1)

H6N2O

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(CCNC(=O)OC(C)(C)C)cc2)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21$

HCID178473948

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)NCCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccc(CN)cc2)cc1$

HCID178453290

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Prepared analogously to Example 140 from (Z)-3-{1-[4-(2-tert.butoxycarbonylamino-ethyl)-phenylamino]-1-(4-phthalimidomethyl-phenyl)-methylidene}-1-acetyl-5-nitro-2-indolinone and hydrazine hydrate solution in ethanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fcd9165954f54a5a90748585608b9c50
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:37]2\[C:38](=[O:52])[N:39](C(=O)C)[C:40]3[C:45]\2=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:26]3C(=O)C4=CC=CC=C4C3=O)=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.NN>C(O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH:17]/[C:18](=[C:37]2\[C:38](=[O:52])[NH:39][C:40]3[C:45]\2=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH2:26])=[CH:21][CH:20]=2)=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]