Methyl 2,5-dimethoxyoxolane-2-carboxylate → Methyl 1-(5-cyano-2-propylimidazol-4-yl)-1H-pyrrole-2-carboxylate

HRID 248635Notes

Reaction equation

HRID 248635 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([CH2:9][CH2:10][CH2:11]C)[NH:5][C:6]=1[C:7]#[N:8].CO[C:15]1([C:22](OC)=O)[CH2:19][CH2:18][CH:17]([O:20][CH3:21])[O:16]1>>[C:7]([C:6]1[NH:5][C:4]([CH2:9][CH2:10][CH3:11])=[N:3][C:2]=1[N:1]1[CH:22]=[CH:15][CH:19]=[C:18]1[C:17]([O:20][CH3:21])=[O:16])#[N:8]

Participants

3

Reactant 2

HCID 13152840Methyl 2,5-dimethoxyoxolane-2-carboxylateHCID 191069144-Amino-2-butyl-5-cyanoimidazole

Product 1

HCID 14962886Methyl 1-(5-cyano-2-propylimidazol-4-yl)-1H-pyrrole-2-carboxylate

Procedure

Using the method of Example 5, 4-amino-5-cyano-2-propylimidazole (Example 7) was reacted with methyl 2,5-dimethoxy-tetrahydrofuran-2-carboxylate to afford the title compound. 1H-NMR 9.4 (br, 2H), 7.3 (m, 1H), 7.2 (m, 1 H), 6.4 (t, 1H), 3.8 (s, 3H), 2.7 (t, 2H), 1.8 (m, 2H), 1.0 (t, 3H).

Sources & evidence

ORD record
ord-d46128baebba4eb4bb18b21333458bd9
Source dataset
uspto-grants-1993_05
Patent number
US05210211

Reaction notes

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