Methyl 2,5-dimethoxyoxolane-2-carboxylate → Methyl 1-(5-cyano-2-propylimidazol-4-yl)-1H-pyrrole-2-carboxylate

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Reaction Steps

Using the method of Example 5, 4-amino-5-cyano-2-propylimidazole (Example 7) was reacted with methyl 2,5-dimethoxy-tetrahydrofuran-2-carboxylate to afford the title compound. 1H-NMR 9.4 (br, 2H), 7.3 (m, 1H), 7.2 (m, 1 H), 6.4 (t, 1H), 3.8 (s, 3H), 2.7 (t, 2H), 1.8 (m, 2H), 1.0 (t, 3H).

Provenance & Evidence