Diisopropyl Ether → 2-Tertbutoxycarbonylamino-7-vinyl-tetraline

HRID 248646Notes

Reaction equation

HRID 248646 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13](OS(C(F)(F)F)(=O)=O)=[CH:14][CH:15]=2)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:27](OC(C)C)(C)[CH3:28]>C(Cl)Cl>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([CH:27]=[CH2:28])=[CH:14][CH:15]=2)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 18651770(2R)2-tertbutoxycarbonylamino-7-trifluoromethanesulfonyloxy-tetraline

Product 1

HCID 193860512-Tertbutoxycarbonylamino-7-vinyl-tetraline

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound is obtained by following the procedure described in Preparation I step b) but starting from the product obtained in step b) above. Yield: 7 g. M.p. 89°-91° C. (isopropyl ether). [α]D20 =+40° (c=0.3%, CH2Cl2).

Workup

  1. customThe compound is obtained
  2. customdescribed in Preparation I step b) but

Sources & evidence

ORD record
ord-c75d1180e1084702a86778b24c790e61
Source dataset
uspto-grants-1993_05
Patent number
US05210276

Reaction notes

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