反应详情

8.96 g (50 mmol) of 4-fluoro-2-trifluoromethylaniline is dissolved in 100 ml of pyridine and under cold conditions combined under stirring with 9.52 g (50 mmol) of 3-chlorosulfonylpropionic acid methyl ester (98.5%). The mixture is agitated for 20 minutes, heated for 4 hours to 40° C., and the pyridine is exhausted under vacuum. The residue is distributed between dichloroethane and 4N hydrochloric acid. The organic solution is washed with water, dried over sodium sulfate, and concentrated to dryness under vacuum. The residue is purified by column chromatrography on silica gel. The title compound is eluted with ethyl acetate.

1. temperatureheated for 4 hours to 40° C.
2. washThe organic solution is washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated to dryness under vacuum
5. customThe residue is purified by column chromatrography on silica gel
6. washThe title compound is eluted with ethyl acetate