Piperazine → 1-(Methylsulfonyl)piperazine

HRID 248810Notes

Reaction equation

HRID 248810 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[OH-].[Na+]>ClCCl>[CH3:1][S:2]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 4837PiperazineHCID 14798Sodium HydroxideHCID 31297Methanesulfonyl chloride

Product 1

HCID 7091611-(Methylsulfonyl)piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of methanesulfonyl chloride (1.85 ml, 24 mmol) and piperazine (2.06 g, 24 mmol) in dichloromethane (60 ml) was stirred at room temperature for 14 hours. The mixture was basified with aqueous sodium hydroxide and filtered. The filtrate was washed with water, dried (magnesium sulfate) and evaporated down to give the title sulfonamide.

Workup

  1. filtrationfiltered
  2. washThe filtrate was washed with water
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated down

Sources & evidence

ORD record
ord-22437d70d6b64f2b8fe89953e9becaaf
Source dataset
uspto-grants-1993_05
Patent number
US05212172

Reaction notes

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