Sodium Hydroxide → HCID 178482197, compound

HRID 24883Notes

Reaction equation

HRID 24883 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[CH3:24][N:25]([C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=1)[S:26]([CH3:29])(=[O:28])=[O:27].[OH-].[Na+]>CN(C=O)C.CO>[CH3:24][N:25]([C:30]1[CH:36]=[CH:35][C:33]([NH:34]/[C:13](=[C:6]2\[C:5](=[O:23])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:32][CH:31]=1)[S:26]([CH3:29])(=[O:27])=[O:28]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 23507434N-(4-Aminophenyl)-N-methylmethanesulfonamideHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178482197HCID 178482197, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and 4-(N-methyl-N-methylsulphonyl-amino)-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-a06d04dadd254343bff0d656e7f06dd5
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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