Phenacyl bromide → HCID 22401744, compound

HRID 248880Notes

Reaction equation

HRID 248880 reaction equation
[CH2:1]([C:8]1[S:12][C:11]([NH2:13])=[N:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[Br:14][CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17]>C(#N)C>[BrH:14].[CH2:1]([C:8]1[S:12][C:11](=[NH:13])[N:10]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:17])[CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 53849091HCID 53849091, compound2×

Product 1

HCID 22401744HCID 22401744, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 6 parts of 5-heptyl-2-thiazolamine (prepared as intermediate 2), 6 parts of 2-bromo-1-phenylethanone and 120 parts of acetonitrile was stirred overnight at room temperature. The precipitate was filtered off, washed with 2,2'-oxybispropane and dried, yielding 10 parts of 2-(5-heptyl-2,3-dihydro-2-imino-3-thiazolyl)-1-phenylethanone hydrobromide (interm. 3).

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with 2,2'-oxybispropane
  3. customdried

Sources & evidence

ORD record
ord-d460859b9707482ba36f7c3c2d40c3a9
Source dataset
uspto-grants-1993_05
Patent number
US05212192

Reaction notes

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