反应详情

Preparation is effected analogously to Example 63, using 0.9 g (2.9 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,2-ethanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.75 g (3.2 mmol) of 2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethaneamine as starting materials. Working up by chromatography (eluant: methylene chloride/methanol 95+5) analogously to Example 63 yields the purified title compound in the form of an oil; MS (+FAB method): m/z (rel. int.[%])=561 ([M+H]+, 3), 155 (26), 230 (100); IR (KBr): 1650 cm+1 (C=O). For analytical purposes a sample is converted into the O,O'-ditoluoyltartaric acid salt and recrystallised from ether/isopropanol; m.p.: from 140° C. with decomposition.

1. customPreparation
2. custompurified title compound in the form of an oil
3. customrecrystallised from ether/isopropanol
4. customfrom 140° C.