Sodium Hydroxide → HCID 178484614, compound

HRID 24901Notes

Reaction equation

HRID 24901 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)/[C:6](=[C:16](/[NH:23][C:24]2[CH:29]=[CH:28][C:27]([NH:30][S:31]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)(=[O:33])=[O:32])=[CH:26][CH:25]=2)\[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)/[C:5]1=[O:40])(=O)C.[CH3:41][N:42]([CH3:47])[C:43](=[O:46])[CH2:44]Br.CC(C)([O-])C.[K+].[OH-].[Na+]>CS(C)=O.CO>[CH3:41][N:42]([CH3:47])[C:43]([CH2:44][N:30]([C:27]1[CH:26]=[CH:25][C:24]([NH:23]/[C:16](=[C:6]2\[C:5](=[O:40])[NH:4][C:12]3[C:7]\2=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=3)/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:29][CH:28]=1)[S:31]([C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)(=[O:33])=[O:32])=[O:46]

Participants

7

Reactant 4

HCID 14798Sodium HydroxideHCID 2255442-Bromo-N,N-dimethylacetamideHCID 23665647Potassium tert-butoxideHCID 178473951N-[4-[[(Z)-(1-acetyl-5-nitro-2-oxoindol-3-ylidene)-phenylmethyl]amino]phenyl]benzenesulfonamide

Product 1

HCID 178484614HCID 178484614, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 887MethanolSolvent

Procedure

Prepared analogously to Examples 82 and 187 from (Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-c1e58ccacf284affa8f5bc6c466b275e
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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