HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → N-[4-[N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]butyl]-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,4-butanediamine | HCID 19762574 | — |
| Reactant | 2-[4-(2-Aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine | HCID 178512723 | — |
| Product | N-[4-[N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]butyl]-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]urea | HCID 178483549 | — |
Reaction Steps
Preparation is effected analogously to Example 63, using 0.20 g (0.6 mmol) of N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,4-butanediamine and the equimolar amounts of 1,1'-carbonyldiimidazole and 2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethaneamine as starting materials. Working up by chromatography analogously to Example 63 yields the purified title compound in the form of a viscous oil. MS (+FAB method): m/z (rel. int. [%])=588 ([M+H]+, 2), 109 (100); IR (KBr): 1685 cm-1 (C=O); C27H38FN9OS2 (587.90).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05212187 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-66cb6553a554442d931be278472b106a |
| Source note | uspto-grants-1993_05 |