HCID 178512865, compound → HCID 178512867, compound

Participants

Reaction Steps

N-carbobenzoxy-O-benzyl-L-aspartyl-O-benzyl-L-seryl-L-aspartyl-L-prolyl-L-arginine (2.7 Kg) is dissolved in 19 L of aqueous 2.3M ammonium acetate. Palladium on charcoal (5-20%) is added. The mixture is purged with nitrogen and then contacted with hydrogen flowing at a rate of 50-100 L/hr for three to sixteen hours at 15°-25° C. and from atmospheric pressure to 50 psig.

Provenance & Evidence