HRID249071

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O

HCID178512865

未命名化合物

PRODUCTS

生成物

结构：N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)O

HCID178512867

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID517165

Ammonium acetate

C2H7NO2

PROCEDURE

实验过程

N-carbobenzoxy-O-benzyl-L-aspartyl-O-benzyl-L-seryl-L-aspartyl-L-prolyl-L-arginine (2.7 Kg) is dissolved in 19 L of aqueous 2.3M ammonium acetate. Palladium on charcoal (5-20%) is added. The mixture is purged with nitrogen and then contacted with hydrogen flowing at a rate of 50-100 L/hr for three to sixteen hours at 15°-25° C. and from atmospheric pressure to 50 psig.

WORKUP

后处理

customThe mixture is purged with nitrogen
waitcontacted with hydrogen flowing at a rate of 50-100 L/hr for three to sixteen hours at 15°-25° C. and from atmospheric pressure to 50 psig

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-647caae8ab604518b84d91e99488df19
来源数据集: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05212287
来源说明: uspto-grants-1993_05

反应 SMILES

C([NH:11][C@H:12]([C:24]([NH:26][C@H:27]([C:37]([NH:39][C@H:40]([C:45]([N:47]1[CH2:65][CH2:64][CH2:63][C@H:48]1[C:49]([NH:51][C@H:52]([C:60]([OH:62])=[O:61])[CH2:53][CH2:54][CH2:55][NH:56][C:57](=[NH:59])[NH2:58])=[O:50])=[O:46])[CH2:41][C:42](=[O:44])[OH:43])=[O:38])[CH2:28][O:29]CC1C=CC=CC=1)=[O:25])[CH2:13][C:14](=[O:23])[O:15]CC1C=CC=CC=1)(OCC1C=CC=CC=1)=O>C([O-])(=O)C.[NH4+].[Pd]>[NH2:11][C@H:12]([C:24]([NH:26][C@H:27]([C:37]([NH:39][C@H:40]([C:45]([N:47]1[CH2:65][CH2:64][CH2:63][C@H:48]1[C:49]([NH:51][C@H:52]([C:60]([OH:62])=[O:61])[CH2:53][CH2:54][CH2:55][NH:56][C:57](=[NH:58])[NH2:59])=[O:50])=[O:46])[CH2:41][C:42](=[O:43])[OH:44])=[O:38])[CH2:28][OH:29])=[O:25])[CH2:13][C:14](=[O:15])[OH:23]