Acetic Anhydride → HCID 19689901, compound

HRID 2491Notes

Reaction equation

[NH2:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([N:8]([CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:33])[C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=2)=[O:7])=[CH:4][C:3]=1[O:36][CH3:37].[C:38](OC(=O)C)(=[O:40])[CH3:39]>>[CH3:37][O:36][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:2]=1[NH:1][C:38](=[O:40])[CH3:39])[C:6]([N:8]([CH2:17][CH2:18][N:19]1[CH2:20][CH2:21][CH:22]([C:25](=[O:33])[C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[CH2:23][CH2:24]1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:7]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 19690047HCID 19690047, compound

Product 1

HCID 19689901HCID 19689901, compoundYield 77.9%

Procedure

Using 4-amino-3-methoxy-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (253.0 mg, 0.50 mmol) and acetic anhydride (0.095 ml, 1.00 mmol), the procedure of inventive Example 94 was repeated to obtain 213.0 mg (77.9%) of the title compound in a yellow amorphous form.

Sources & evidence

ORD record: ord-36584347913d4b168f2b2a55aee4be5c
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728835

Reaction notes

Loading…