HCID 57165886, compound → HCID 15222216, compound

HRID 249112Notes

Reaction equation

HRID 249112 reaction equation
[F:1][C:2]([F:27])([CH2:23][CH2:24][CH2:25][CH3:26])[C:3](=[O:22])[CH:4]=[CH:5][C@H:6]1[C@H:13]([O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][O:16]2)[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:21])[O:10]2>[Pd].C(OCC)(=O)C>[F:27][C:2]([F:1])([CH2:23][CH2:24][CH2:25][CH3:26])[C:3](=[O:22])[CH2:4][CH2:5][C@H:6]1[C@H:13]([O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][O:16]2)[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:21])[O:10]2

Participants

4

Reactant 1

HCID 57165886HCID 57165886, compound

Product 1

HCID 15222216HCID 15222216, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The compound (50) (12.7 g) was catalytically hydrogenated over 5% palladium on carbon (catalytic amount) in ethyl acetate (300 ml) under hydrogen atmosphere to give the titled compound (51). Yield: 12.5 g (99%).

Sources & evidence

ORD record
ord-3409fda0d768421fb94633c644113aa4
Source dataset
uspto-grants-1993_05
Patent number
US05212324

Reaction notes

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