Sodium borohydride → hexahydro-cyclopenta[b]furan-2-one

HRID 249113Notes

Reaction equation

HRID 249113 reaction equation
FC(F)(CCCC)C(=O)CC[C@H:6]1[C@H:13](OC2CCCCO2)[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:21])[O:10]2.[BH4-].[Na+]>CO>[CH:11]12[CH2:12][CH2:13][CH2:6][CH:7]1[CH2:8][C:9](=[O:21])[O:10]2

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 15222216HCID 15222216, compound

Product 1

HCID 11665410hexahydro-cyclopenta[b]furan-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (51) (12.6 g) was reduced with sodium borohydride (1.25 g) in methanol (400 ml) at 0° C. to give the titled compound (52). Yield: 12.1 g (95.5%).

Sources & evidence

ORD record
ord-28223cfe1a7244de82a44afb1dbd7311
Source dataset
uspto-grants-1993_05
Patent number
US05212324

Reaction notes

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