hexahydro-cyclopenta[b]furan-2-one → HCID 12645859, compound

HRID 249114Notes

Reaction equation

HRID 249114 reaction equation
[CH:1]12[CH2:8][CH2:7][CH2:6][CH:5]1[CH2:4][C:3](=[O:9])[O:2]2.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[CH:1]12[CH2:8][CH2:7][CH2:6][CH:5]1[CH2:4][CH:3]([OH:9])[O:2]2

Participants

4

Reactant 2

HCID 11665410hexahydro-cyclopenta[b]furan-2-oneHCID 21225700Diisobutylaluminumhydride

Product 1

HCID 12645859HCID 12645859, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound (52) (12.1 g) was reduced with diisobutylaluminum hydride (1.5M, 65.1 ml) in toluene (500 ml) at -78° C. and the obtained crude product was subjected to silicagel column chromatography to give the titled compound (53). Yield: 11.1 g (91%).

Workup

  1. customthe obtained crude product

Sources & evidence

ORD record
ord-2863b25a99c34b2eab7783f4c5b30bec
Source dataset
uspto-grants-1993_05
Patent number
US05212324

Reaction notes

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