Hydrochloric Acid → HCID 67828138, compound

HRID 249177Notes

Reaction equation

[CH2:1]([C:5]1[CH:61]=[CH:60][C:8]([CH2:9][N:10]([C:18]2[CH:19]=[C:20]([CH:38]=[C:39]([N:41](C(OC(C)(C)C)=O)[CH2:42][C:43]3[CH:48]=[CH:47][C:46]([CH2:49][CH:50]([CH3:52])[CH3:51])=[CH:45][CH:44]=3)[CH:40]=2)[C:21]([C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[CH:24]=2)=[O:22])C(OC(C)(C)C)=O)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[ClH:62].CCCCCC>C1(C)C=CC=CC=1.O1CCOCC1>[ClH:62].[ClH:62].[CH2:49]([C:46]1[CH:45]=[CH:44][C:43]([CH2:42][NH:41][C:39]2[CH:38]=[C:20]([CH:19]=[C:18]([NH:10][CH2:9][C:8]3[CH:60]=[CH:61][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:6][CH:7]=3)[CH:40]=2)[C:21]([C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[CH:24]=2)=[O:22])=[CH:48][CH:47]=1)[CH:50]([CH3:52])[CH3:51]

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of 4-[3-[3,5-bis[N-(4-isobutylbenzyl)-N-tert-butoxycarbonylamino]benzoyl]indol-1-yl]butyric acid (1.02 g) in toluene (10 ml) was added 4N solution of hydrogen chloride in 1,4-dioxane (30 ml) at 25° C. The mixture was stirred at 25° C. for 1 hour, and then hexane (30 ml) was added. The precipitates were filtered and washed with isopropyl ether and hexane to give 4-[3-[3,5-bis[(4-isobutylbenzyl)amino]benzoyl]indol-1-yl]butyric acid dihydrochloride (688 mg) as white powder.

Workup

filtrationThe precipitates were filtered
washwashed with isopropyl ether and hexane

Sources & evidence

ORD record: ord-cbe661459b0d473ba43a66a68adead1f
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05212320

Reaction notes

Loading…