反应详情

温度

52 °C

10% Sodium hydroxide solution (170 mL, 0.424 mol) is added to a solution of ethyl 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionate (79.09 g, 0.212 mol) in tetrahydrofuran with stirring. The reaction mixture is heated to 52° C., stirred for 3 hours, concentrated in vacuo and diluted with water. The aqueous solution is washed with methylene chloride, acidified with concentrated sulfuric acid and extracted with ethyl acetate. The combined organic extracts are dried and concentrated in vacuo to give the title product as a white solid (48.7 g) which is identified by 1H NMR spectral analysis.

1. stirringstirred for 3 hours
2. concentrationconcentrated in vacuo
3. additiondiluted with water
4. washThe aqueous solution is washed with methylene chloride
5. extractionextracted with ethyl acetate
6. customThe combined organic extracts are dried
7. concentrationconcentrated in vacuo