反应详情

温度

0 °C

Triethylamine is added to a stirred mixture of L-cysteine ethyl ester hydrochloride (2.71 g, 14.66 mmol) in chloroform under nitrogen. After the reaction mixture is cooled to 0° C., a solution of 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionyl chloride (5.08 g, 1 4.66 mmol) in chloroform (30 mL) is added dropwise with stirring. The reaction mixture is then stirred overnight at room temperature, concentrated in vacuo and filtered to obtain a semi-solid. Chromatography of the semi-solid using silica gel and eluting with methylene chloride followed by 2% to 5% ethyl acetate in methylene chloride gives the title product as a white solid, mp 89°-91° C.

1. stirringThe reaction mixture is then stirred overnight at room temperature
2. concentrationconcentrated in vacuo
3. filtrationfiltered
4. customto obtain a semi-solid
5. washeluting with methylene chloride