反应详情

9.4 g (50 mmol) of 4-nitrobenzylamine-hydrochloride, 11.7 g (110 mmol) of sodium carbonate and 7.5 g (50 mmol) of sodium iodide are added to a solution of 5.7 g (50 mmol) of 2-chloropyrimidine in 250 ml of ethanol. The mixture is refluxed for 20 hours. Then the salts are removed by suction filtering, the filtrate is evaporated down and taken up in 300 ml of ethyl acetate. It is washed with water, the solvent is eliminated in vacuo and the residue is chromatographed on silica gel (dichloromethane/methanol=97:3).

1. temperatureThe mixture is refluxed for 20 hours
2. customThen the salts are removed by suction
3. filtrationfiltering
4. customthe filtrate is evaporated down
5. washIt is washed with water
6. customthe residue is chromatographed on silica gel (dichloromethane/methanol=97:3)