反应详情

Benzophenone oxime (3.94 g, 20 mmol), 1-bromo-2-chloroethane (28.7 g, 200 mmol) and dried, powdered potassium carbonate (5.53 g, 80 mmol) in acetone (60 ml) were heated at reflux for 72 h. The reaction mixture was cooled and filtered and the filtrate was evaporated to an oily residue which was purified by "flash" chromatography (eluting with heptane/ethyl acetate 19/1) to provide diphenylmethanone O-(2-chloroethyl)oxime (3.82 g, 73%) as an oil, tlc rf 0.36 (SiO2, heptane/ethyl acetate 9/1).

1. temperaturewere heated
2. temperatureat reflux for 72 h
3. temperatureThe reaction mixture was cooled
4. filtrationfiltered
5. customthe filtrate was evaporated to an oily residue which
6. customwas purified by "flash" chromatography (eluting with heptane/ethyl acetate 19/1)