Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | 2-Chloro-4,5-difluoro-alpha-oxobenzenepropanoic acid ethyl ester | HCID 53662473 | — |
| 생성물 | Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54163438 | — |
반응 단계
2-Chloro-4,5-difluoro-α-oxo-benzenepropanoic acid ethyl ester (20 g, 76 mmol), triethylorthoformate (17.0 g, 115 mmol) and acetic anhydride (19.5 g, 191 mmol) were combined and heated to reflux for 3 hours. Excess solvent was removed in vacuo to provide the crude title product, which was used without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05214051 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-6a1227d77b4c4ea1b9035e0775679ef6 |
| 출처 메모 | uspto-grants-1993_05 |