Phenacylamine → 2-Aminoacetophenone 3-chlorophenylhydrazone

HRID 249316ノート

反応式

HRID 249316 の反応式
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][NH2:19])[CH:15]=[CH:16][CH:17]=1>CC(O)=O.CCO.O>[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][N:19]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2][NH2:1])[CH:15]=[CH:16][CH:17]=1

参加物

6

反応物 2

HCID 11952PhenacylamineHCID 75332(3-Chlorophenyl)hydrazine

生成物 1

HCID 867463502-Aminoacetophenone 3-chlorophenylhydrazone収率 86.1%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 3.12 g 2-aminoacetophenone and 3.29 g 3-chlorophenylhydrazine in 4 ml HOAc and 20 ml EtOH was refluxed for one hour. The cooled reaction mixture was diluted with water and the precipitate was collected, washed with water, and dried to give 5.16 g solid. Recrystallization from methanol gave 2.12 g solid, m.p. 131°-134° C.

後処理

  1. temperaturewas refluxed for one hour
  2. customThe cooled reaction mixture
  3. customthe precipitate was collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-f0fb4ee128634fbc8c8d3a1e252fae6f
出典データセット
uspto-grants-1993_05
特許番号
US05214059

反応ノート

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