反应详情

温度

0 °C

Octyl chloroformate (2.00 ml) was added dropwise to a solution of 2.15 g 2-(2-aminophenyl)-2,3-dihydro-1H-indole and 2.00 ml pyridine in 35 ml CH2Cl2 at 0° C. The solution was stirred five hours at 0° C. and then quenched with water. The organic layer was separated, washed with 5% HCl and saturated NaCl solution, dried (MgSO4), and concentrated to yield a solid. Purification by flash chromatography using CH2Cl2 /hexane (1:2) as eluent gave 1.74 g solid, m.p. 99°-102° C.

1. customquenched with water
2. customThe organic layer was separated
3. washwashed with 5% HCl and saturated NaCl solution
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customto yield a solid
7. customPurification by flash chromatography