HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-[2-(Octyloxycarbonylamino)phenyl]-2,3-dihydro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Reactant | 2-(2-Aminophenyl)-2,3-dihydro-1H-indole | HCID 19761420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[2-(Octyloxycarbonylamino)phenyl]-2,3-dihydro-1H-indole | HCID 19761413 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
Octyl chloroformate (2.00 ml) was added dropwise to a solution of 2.15 g 2-(2-aminophenyl)-2,3-dihydro-1H-indole and 2.00 ml pyridine in 35 ml CH2Cl2 at 0° C. The solution was stirred five hours at 0° C. and then quenched with water. The organic layer was separated, washed with 5% HCl and saturated NaCl solution, dried (MgSO4), and concentrated to yield a solid. Purification by flash chromatography using CH2Cl2 /hexane (1:2) as eluent gave 1.74 g solid, m.p. 99°-102° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05214059 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-783e13f337c74e3eacd77cdfc62a8bcc |
| Source note | uspto-grants-1993_05 |