Methylamine → 1-[4-(Methylamino)piperidin-1-yl]ethan-1-one

HRID 249345Notes

Reaction equation

HRID 249345 reaction equation
[CH3:1][NH2:2].[C:3]([N:6]1[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]1)(=[O:5])[CH3:4]>C(O)C.[Pt]=O>[C:3]([N:6]1[CH2:11][CH2:10][CH:9]([NH:2][CH3:1])[CH2:8][CH2:7]1)(=[O:5])[CH3:4]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 122563N-Acetyl-4-piperidone

Product 1

HCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent2×

Procedure

9.9 g of methylamine in 50 ml of ethanol are added to 14.4 g of 1-acetyl-4-oxopiperidine in 100 ml of ethanol. The mixture is then hydrogenated in the presence of platinum oxide at room temperature and atmospheric pressure, filtered and evaporated.

Workup

  1. filtrationatmospheric pressure, filtered
  2. customevaporated

Sources & evidence

ORD record
ord-09755d2c13bd4690b4e6ad1e4fbd6087
Source dataset
uspto-grants-1993_05
Patent number
US05214055

Reaction notes

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