Propargyl bromide → HCID 19761510, compound

HRID 249382Notes

Reaction equation

[CH3:1][O:2][C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=2)[CH:9]=1)([CH2:6][CH3:7])[CH2:4][OH:5].[CH2:26](Br)[C:27]#[CH:28]>>[CH2:28]([O:5][CH2:4][C:3]([O:2][CH3:1])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=2)[CH:9]=1)[CH2:6][CH3:7])[C:27]#[CH:26]

Participants

Reactant 2

HCID 7842Propargyl bromide

HCID 19761508HCID 19761508, compound

Product 1

HCID 19761510HCID 19761510, compoundYield 92%

Procedure

Using the procedure described in Example 8, 2-methoxy-2-[3-(naphth-2-ylmethoxy)phenyl]butan-1-ol (Example 6) with reacted with prop-2-ynyl bromide to give 2-methoxy-2-[3-(naphth-2-ylmethoxy)phenyl]but-1-yl prop-2-ynyl ether in 92% yield, m.p. 54° C.

Sources & evidence

ORD record: ord-4e2a37848e81481db2804dc01eb0819d
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05214069

Reaction notes

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